Professor Robert MacLaren : Ophthalmology

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Professor Robert MacLaren

Not Fee assured
Awaiting verification
Not in Open Referral network

Overview

Specialises in

Medical

Surgical

Surgical retinal

About me

Robert MacLaren is Professor of Ophthalmology at the University of Oxford, Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology, Honorary Consultant Vitreoretinal Surgeon at Moorfields Eye Hospital, Honorary Consultant Ophthalmologist at Great Ormond Street Children's Hospital, Faculty Member and Founding Theme Leader of the Moorfields-UCL, Institute of Ophthalmology Biomedical Research Centre. From 2010-2012 he was also Theme Leader for Brain Research at the Oxford Biomedical Research Centre. He is also a Fellow of the Royal College of Ophthalmologists, Fellow of the Royal College of Surgeons of Edinburgh, Fellow of the American College of Surgeons, Fellow of the Academy of Medical Sciences and Bodley Fellow of Merton College Oxford.

Previous notable achievements in ophthalmic surgery include defining the equations for lens power predictions for cataract surgery in extreme myopia (J Cataract Refract Surg 2005) and hyperopia (Am J Ophthalmol 2007); the first in human gene therapy trial for choroideremia (Lancet 2014; New Engl J Med 2016; Nature Med 2018); the first ever use of a robot to operate inside the human eye (Nature Biomed Eng 2018); the first gene therapy treatment to reverse vision loss in retinitis pigmentosa (Nature Med, 2020) and the first gene therapy trial for the dry form of age-related macular degeneration, together with Gyroscope Therapeutics (www.bbc.co.uk/news/health-47226987).

Although listed as 'not fee assured', all surgical and outpatient fees will be charged as per Bupa guidelines. Cataract patients will however be offered the full range of intraocular lenses, many of which are not covered by Bupa reimbursement. Therefore patients opting for some of the more advanced lenses (e.g. multifocal) may incur an additional shortfall outside of their policy.

Areas of interest

Cataract surgery; Cataracts; Age related macular degeneration (AMD); Eyes; Diabetic retinopathy; Retinal disease / surgery; Visual disorders; Medical retina; Vitreoretinal surgery; Anterior segment surgery (eyes);

Medical secretaries

Raluca Guta
Practice Manager to Prof MacLaren Nuffield Health The Manor Hospital Beech Road Headington Oxford OX3 7RP
01865 307768
raluca.guta@nuffieldhealth.com

Anaesthetists worked with

Dr Sumit Das Not Fee Assured
Professor Andrew Farmery Not Fee Assured

Dr Peter Cole Not Fee Assured

About me

Current NHS consultant posts held

Consultant Ophthalmologist at the Oxford Eye Hospital and Honorary Consultant at Moorfields Eye Hospital

Research interests

Clinical and laboratory research is dedicated to finding new treatments for blindness, particularly in patients with incurable retinal diseases. Includes developing gene therapy with adeno-associated viral (AAV) vectors in the lab and in forthcoming clinical trials.

A clinical research program in artificial vision with bio-genetic and electronic devices. Developing new eye surgery techniques for age-related macular degeneration, cataract and macular hole surgery.

Personal interests

Prior to ophthalmology, Robert was commissioned into the Royal Army Medical Corps. He saw active service as a Section Commander with 16 Armoured Field Ambulance and latterly served as the Surgeon Major to the Honourable Artillery Company in London. He remains a keen supporter of the military and provides concessions for former service personnel. In 2004 he was awarded the Volunteer Reserves Service Medal (VR) and in 2011 he was appointed as Civilian Consultant Advisor to the Royal Navy.

Awards received

2020 Lang Lecture and Medal, Royal Society of Medicine
2020 Senior Investigator Award, National Institute for Health Research
2019 Clinical Service of the Year Award, the Macular Society
2019 Keeler Lecture and Medal, Royal College of Ophthalmologists
2019 Gold Clinical Excellence Award for NHS service delivery
2018 Sir Adrian Cadbury Lecture and Medal, Midland Ophthalmological Society
2018 American Academy of Ophthalmology Achievement award

Publications

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR.
Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia.
Xue K. et al, (2018), Nature Medicine, 24, 1507 - 1512

First-in-human study of the safety and viability of intraocular robotic surgery.
Edwards TL. et al, (2018), Nature Biomedical Engineering, 2, 649 - 656

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.
De Silva SR. et al, (2017), Proceedings of the National Academy of Sciences, 114, 11211 - 11216

Visual Acuity after Retinal Gene Therapy for Choroideremia.
Edwards TL. et al, (2016), N Engl J Med, 374, 1996 - 1998

Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization.
Charbel Issa P. et al, (2015), Proc Natl Acad Sci U S A, 112, 8415 - 8420

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.
MacLaren RE. et al, (2014), Lancet, 383, 1129 - 1137

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Singh MS. et al, (2013), Proc Natl Acad Sci USA, 110, 1101 - 1106

Retinal repair by transplantation of photoreceptor precursors.
MacLaren RE. et al, (2006), Nature, 444, 203 - 207

About my work

View photos of my work

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View photos of my team

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My qualifications & training

Qualifications

FMedSci Academy of Medical Sciences 2018
FACS American College of Surgeons 2017
FRCOphth Royal College of Ophthalmologists 2004
FRCS (Edin) Royal College of Surgeons of Edinburgh 1998
DPhil University of Oxford 1996
MB ChB University of Edinburgh 1990

GMC registration

Reference number 3493087

Professional bodies (positions held - last 3 yrs)

Specialist Advisor The National Institute for Health and Care Excellence (NICE) 2019
Civilian Consultant Advisor The Royal Navy 2011

Details of entry to specialist register

Specialist Register (Ophthalmology) , 2003

My private practice

Information for healthcare professionals (Bupa patients only, last 12 months)

Procedures completed

C7122
Ultrasound phacoemulsification of cataract, with lens implant - unilateral (including topical or local anaesthetic) - (5-50)

Nuffield Health The Manor Hospital (5-50) Moorfields Eye Hospital (1-5)
C7982
Pars plana vitrectomy with internal tamponade, scleral buckling and retinopexy with dissection or excision of epiretinal membrane/macular surgery - (1-5)

Nuffield Health The Manor Hospital (1-5)
C7340
Yag laser photodisruption of posterior capsule of lens (including laser capsulotomy) - unilateral - (1-5)

Nuffield Health The Manor Hospital (1-5)
C7341
Yag laser photodisruption of posterior capsule of lens (including laser capsulotomy) - bilateral - (1-5)

Nuffield Health The Manor Hospital (1-5)

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